Carbachol induction of REM sleep in the rat is more effective at lights-out than lights-on

  • Marks G
  • Birabil C
  • 3

    Readers

    Mendeley users who have this article in their library.
  • 6

    Citations

    Citations of this article.

Abstract

Long-lasting increases in REM sleep are induced in the rat following injection of small amounts of muscarinic receptor agonists into the caudal oral pontine reticular formation. By injecting carbachol at the beginning of the light period or beginning of the dark period, we sought to determine whether the muscarinic, REM sleep induction is influenced by the time of day it is initiated. We found that carbachol is more effective at increasing REM sleep when administered at the beginning of the dark in 87% of the cases. Of these cases, 43% showed evidence of a decreased potency of carbachol by a shift in the dose-response curve to the right. The lack of agreement in efficacy and potency to increase REM sleep supports a conclusion that alterations in local muscarinic receptors are not mediating the effect of time of day. REM sleep control mechanisms down stream of the muscarinic receptors may be the responsible factors. © 2007 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • Circadian control
  • Homeostatic control
  • Muscarinic
  • Pontine reticular formation

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Gerald A. Marks

  • Christian G. Birabil

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free