Carrageenan-induced inflammation alters the content of i-cGMP and i-cAMP in the dorsal horn of the spinal cord

  • Garry M
  • Richardson J
  • Hargreaves K
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Abstract

Hindpaw injections of carrageenan (CARRA) decreased paw withdrawal latencies to radiant heat and increased hindpaw edema. At the peak of hyperalgesia, the content of immunoreactive guanosine 3′,5′-cyclic monophosphate (i-cGMP) was increased, while immunoreactive adenosine 3′,5′-cyclic monophosphate (i-cAMP) was decreased in lumbar, but not cervical dorsal horn. In general, the content of i-cGMP in the dorsal horn was correlated with thermal hyperalgesia throughout the course of this model. These results indicate that a peripheral inflammation alters the content of i-cGMP and i-cAMP in the spinal cord and, further, suggest that these nucleotides are involved in the modulation of hyperalgesia in the spinal cord. © 1994.

Author-supplied keywords

  • Carrageenan Inflammation
  • Dorsal horn
  • Hyperalgesia
  • Immunoreactive cAMP
  • Immunoreactive cGMP

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Authors

  • Mary G. Garry

  • Jennelle Durnett Richardson

  • Kenneth M. Hargreaves

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