cDNA sequence for bovine ribosomal protein L3 carrying a bipartite nuclear targeting motif, identified also in many other ribosomal proteins

  • Simonic T
  • Gaudi S
  • Giussani F
 et al. 
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A full-length cDNA encoding bovine ribosomal protein L3 was isolated and sequenced. The deduced protein sequence comprises 403 amino acids and shows a high level of identity with the other known mammalian L3 proteins. Southern blot analysis of bovine genomic DNA suggests that the bovine genome contains at least 4 copies of the L3 gene. A single hybridisation band of about 1.3 kb is detectable by Northern blot analysis. Within the amino acid sequence, two potential nuclear targeting sequences were detected: one at the N-terminal end and the other, consisting in a bipartite motif (amino acids 341 to 358), present and not previously noticed also in the other known mammalian L3 proteins. A search on all the available mammalian ribosomal proteins revealed the presence of this bipartite motif in many of these proteins. © 1994.

Author-supplied keywords

  • Bipartite motif
  • Bovine
  • Nuclear targeting
  • Ribosomal protein L3
  • cDNA

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  • Tatjana Simonic

  • Fiorella Giussani

  • Massimo Malcovati

  • Severino Ronchi

  • Maria Luisa Tenchini

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