Chapter 25 Miniature and Microchip Technologies

  • Fintschenko Y
  • Kirby B
  • Hasselbrink E
 et al. 
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A review. Chip-based devices hold great promise because of the potential for integration. The ability to use photolithog. to define connected structures and a single substrate, such as the glass wafer used to hold these structures, has tremendous appeal. The dimensions that can be manufd. in a variety of materials are on the order of a few microns, dimensions that are appealing to anal. chemists because they translate to the improvement in sepn. speed and efficiency. However, there are a great many challenges to integrating the components required for a successful mTAS. The porous polymer monolith (PPM) has an astonishing versatility in structure. Tuning its chem. has been reported to change relatively minor features, such as charge, to major structural and functional shifts, such as high-pressure pumps and valves. This is exciting, because the PPM, like the chip, is amenable to photolithog. It is introduced as a monomer, usually by capillary action, eliminating the hurdles of chip connections for fabrication. However, there are still areas of significant work to be done. The PPM used for sepn. media, valves, and pumps are still in the early stages of research and development. The properties of the PPM match the requirements of the planar chip structure to such a degree it is possible that every component required for complex JTAS incorporating SPE, chromatog., mixers, pumps, and valves could be fashioned solely based on PPM chem. [on SciFinder (R)]

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  • Yolanda Fintschenko

  • Brian J. Kirby

  • Ernest F. Hasselbrink

  • Anup K. Singh

  • Timothy J. Shepodd

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