Elements that interact constitute a network whose nodes, or vertices, are the elements in interaction and the edges, or links, the interactions between the elements. In this perspective, any biological system can be considered a network. This chapter offers a general view of the science of networks as applied to biological systems. The following points are of particular interest: random graphs, percolation as a model for the emergence of organization in a network, small-world and scale-free networks with a particular emphasis on metabolic networks, and attack tolerance of networks. © 2006 Elsevier B.V. All rights reserved.
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