Characteristics of Ca2+channel blockade by oxodipine and elgodipine in rat cardiomyocytes

  • Galán L
  • Talavera K
  • Vassort G
 et al. 
  • 3


    Mendeley users who have this article in their library.
  • 15


    Citations of this article.


The two novel dihydropyridines, oxodipine and elgodipine greatly depressed the KCl-induced contraction of rabbit aorta and decreased the cardiac force of contraction of rat ventricular strips with lower potency. Both compounds markedly shortened cardiac action potentials. In rat cultured neonatal ventricular myocytes, oxodipine and elgodipine decreased the L-type Ca2+current (I(CaL)) with IC50of 0.24 and 0.33 μM respectively while oxodipine was slightly more potent on the T-type Ca2+current (I(CaT)) than elgodipine (IC50=0.41 vs. 2.18 μM). Both compounds were less potent in inhibiting I(CaL) of adult cardiomyocytes. Oxodipine exhibited mostly a tonic block of both currents while elgodipine induced mainly a use-dependent block. Oxodipine and elgodipine increased by at least one order of magnitude their inhibitory potency on I(CaT) and I(CaL) when the cells were partially depolarized. We conclude that the mechanisms of inhibition of Ca2+channels by these two dihydropyridines are different and suggest that the underlying mechanism of vascular selectivity is the voltage-dependent block of I(CaL), with the use-dependent inhibition of Ca2+currents by elgodipine further contributing to this selectivity. Copyright (C) 1998 Elsevier Science B.V.

Author-supplied keywords

  • 1,4-Dihydropyridine
  • Ca2+channel antagonist
  • Heart
  • Patch-clamp
  • Vascular selectivity

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Loipa Galán

  • Karel Talavera

  • Guy Vassort

  • Julio L. Alvarez

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free