Characteristics of Ca2+channel blockade by oxodipine and elgodipine in rat cardiomyocytes

15Citations
Citations of this article
3Readers
Mendeley users who have this article in their library.
Get full text

Abstract

The two novel dihydropyridines, oxodipine and elgodipine greatly depressed the KCl-induced contraction of rabbit aorta and decreased the cardiac force of contraction of rat ventricular strips with lower potency. Both compounds markedly shortened cardiac action potentials. In rat cultured neonatal ventricular myocytes, oxodipine and elgodipine decreased the L-type Ca2+current (I(CaL)) with IC50of 0.24 and 0.33 μM respectively while oxodipine was slightly more potent on the T-type Ca2+current (I(CaT)) than elgodipine (IC50=0.41 vs. 2.18 μM). Both compounds were less potent in inhibiting I(CaL) of adult cardiomyocytes. Oxodipine exhibited mostly a tonic block of both currents while elgodipine induced mainly a use-dependent block. Oxodipine and elgodipine increased by at least one order of magnitude their inhibitory potency on I(CaT) and I(CaL) when the cells were partially depolarized. We conclude that the mechanisms of inhibition of Ca2+channels by these two dihydropyridines are different and suggest that the underlying mechanism of vascular selectivity is the voltage-dependent block of I(CaL), with the use-dependent inhibition of Ca2+currents by elgodipine further contributing to this selectivity. Copyright (C) 1998 Elsevier Science B.V.

Cite

CITATION STYLE

APA

Galán, L., Talavera, K., Vassort, G., & Alvarez, J. L. (1998). Characteristics of Ca2+channel blockade by oxodipine and elgodipine in rat cardiomyocytes. European Journal of Pharmacology, 357(1), 93–105. https://doi.org/10.1016/S0014-2999(98)00543-3

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free