Chemical and physical properties of cholera exo-enterotoxin (choleragen) and its spontaneously formed toxoid (choleragenoid)

  • Lospalluto J
  • Finkelstein R
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Abstract

The chemical properties of two proteins, cholera enterotoxin (choleragen) and a spontaneously formed toxoid (choleragenoid), have been studied. The toxin has a molecular weight of 84 000 and most likely consists of six subunits with molecular weights of approx. 15 000. The toxin molecule appears to consist of more than one type of subunit. Choleragenoid consists of a mixture of at least three proteins with molecular weights of 58 000 and 4 subunits of approximately equal size. Neither protein contains significant quantities of lipid or hexose. © 1972.

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Authors

  • Joseph J. Lospalluto

  • Richard A. Finkelstein

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