Chemoenzymatic polymer-supported liquid phase synthesis of glucose γ-aminobutyric ester

  • De Torres C
  • Fernández-Mayoralas A
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Abstract

A concise, polymer-supported solution synthesis of 6-O-(γ-aminobutyryl)-D-glucose has been achieved. Glucose was attached to polyethylene glycol monomethyl ether (MPEG) through an α,α′-dioxyxylyl diether linker, and, subsequently, the HO-6 hydroxyl of the glucose was regioselectively esterified with γ-aminobutyric acid by a lipase-catalyzed reaction. © 2003 Elsevier Science Ltd. All rights reserved.

Author-supplied keywords

  • Glucose γ-aminobutyric acid ester
  • Lipase
  • Polymer-supported solution synthesis
  • Regioselective acylation

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