Chronic nicotine treatment potentiates behavioral responses to dopaminergic drugs in rats

  • Katsuya Suemaru
  • Yutaka Gomita
  • Katsushi Furuno
 et al. 
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Abstract

In the present study, the behavioral effects of apomorphine, methamphetamine, and haloperidol were examined in nicotine-treated rats. All animals were SC administered nicotine at a dose of 0.5 mg/kg or saline oncedaily for 14 days. Hyperlocomotion induced by apomorphine (0.2 mg/kg, IP) and methamphetamine (1.0 mg/kg, IP) was greater in nicotine-treated rats than in control rats. Stereotyped behaviors induced by apomorphine (1.0 mg/kg, IP) and methamphetamine (5.0 mg/kg, IP) were also potentiated in nicotine-treated rats. However, the incidence of catalepsy induced by haloperidol (0.25-1.5 mg/kg, IP) was slightly lower in nicotine-treated rats. These results suggest that chronic nicotine treatment may increase the susceptibility of the dopaminergic system to dopaminergic drugs. © 1993.

Author-supplied keywords

  • Apomorphine
  • Catalepsy
  • Chronic treatment
  • Haloperidol
  • Locomotor activity
  • Methamphetamine
  • Nicotine
  • Stereotyped behavior

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