Chronic nicotine treatment potentiates behavioral responses to dopaminergic drugs in rats

35Citations
Citations of this article
2Readers
Mendeley users who have this article in their library.
Get full text

Abstract

In the present study, the behavioral effects of apomorphine, methamphetamine, and haloperidol were examined in nicotine-treated rats. All animals were SC administered nicotine at a dose of 0.5 mg/kg or saline oncedaily for 14 days. Hyperlocomotion induced by apomorphine (0.2 mg/kg, IP) and methamphetamine (1.0 mg/kg, IP) was greater in nicotine-treated rats than in control rats. Stereotyped behaviors induced by apomorphine (1.0 mg/kg, IP) and methamphetamine (5.0 mg/kg, IP) were also potentiated in nicotine-treated rats. However, the incidence of catalepsy induced by haloperidol (0.25-1.5 mg/kg, IP) was slightly lower in nicotine-treated rats. These results suggest that chronic nicotine treatment may increase the susceptibility of the dopaminergic system to dopaminergic drugs. © 1993.

Cite

CITATION STYLE

APA

Katsuya Suemaru, Yutaka Gomita, Katsushi Furuno, & Yasunori Araki. (1993). Chronic nicotine treatment potentiates behavioral responses to dopaminergic drugs in rats. Pharmacology, Biochemistry and Behavior, 46(1), 135–139. https://doi.org/10.1016/0091-3057(93)90329-R

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free