cDNA's coding for cytochrome P4501A1 (CYP1A1), phenol UDP-glucuronosyltransferase (UDPGT) and glutathione S-transferase (GST-A) were cloned and sequenced from an expression library prepared from the liver of a 3-methylcholanthrene (3-MC) induced plaice. Plaice CYP1A1 and Phenol UDPGT display a high degree of structural conservation with homologous mammalian isoforms and their mRNAs were shown to be highly induced in liver after 3-MC treatment of fish. Expression of plaice GST-A, which displays closer homology to GSTs from plants and invertebrates than those of mammals, is repressed after 3-MC treatment. © 1995.
Pirrit, L., Healey, R., Assheton, H., Leaver, M. J., & George, S. G. (1995). Cloning of the major 3-MC inducible phase I and phase II detoxification enzymes of plaice liver. Marine Environmental Research, 39(1–4), 15–19. https://doi.org/10.1016/0141-1136(94)00065-W