Co-localization of neuropeptide Y, vasoactive intestinal polypeptide and dynorphin in non-noradrenergic axons of the guinea pig uterine artery

  • Morris J
  • Gibbins I
  • Furness J
 et al. 
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Abstract

Two major populations of perivascular axons containing immunoreactivity to neuropeptide Y (NPY) have been revealed in the main uterine artery of the guinea pig by immunohistochemical procedures which allow the simultaneous visualization of two antigens. One population contained immunoreactivity to dopamine-β-hydroxylase (DβH) and was presumably noradrenergic. The other main population of axons with NPY-like immunoreactivity (NPY-LI) did not have DβH-like immunoreactivity (DβH-LI) and was presumably non-noradrenergic. These non-noradrenergic axons also contained immunoreactivity to vasoactive intestinal polypeptide (VIP) and dynorphin (DYN). Indeed, nearly all axons with VIP-LI also contained NPY-LI and DYN-like immunoreactivity (DYN-LI). NPY constricted the uterine artery perfused in vitro, whilst VIP dilated uterine arteries preconstricted with noradrenaline or NPY. Thus, we have evidence for the coexistence of a vasoconstrictor peptide and a vasodilator peptide in the same non-noradrenergic perivascular axons, which also contain an opioid peptide, dynorphin. © 1985.

Author-supplied keywords

  • colocalization
  • dynorphin
  • guinea pig
  • immunohistochemistry
  • neuropeptide Y
  • perivascular axon
  • vasoactive intestinal polypeptide

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Authors

  • J. L. Morris

  • I. L. Gibbins

  • J. B. Furness

  • M. Costa

  • R. Murphy

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