Comparative efficacy and tolerability of fusidic acid/hydrocortisone cream (Fucidin?? H cream) and miconazole/hydrocortisone cream (Daktacort?? cream) in infected eczema

  • Poyner T
  • Dass B
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Abstract

Aim. To study the efficacy, tolerability and acceptability of 2% fusidic acid and 1% hydrocortisone with 2% miconazole and 1% hydrocortisone Subject Atopic dermatitis and topical therapy flammatory remedies. Methods. A randomised, open, parallel group comparison. Results. 207 patients with clinically infected eczema were included in a trial with either 2% fusidic acid and 1% hydrocortisone or 2% miconazole and 1% hydrocortisone. At the end of treatment, there was no statistically significant difference between treatments in the preparations of patients 'cleared' or 'markedly improved' (fusidic acid 69.5%, miconazole 68.6%). After 1 week treatment, there was a statistically significant difference in the overall treatment response in favour of fusidic acid/hydrocortisone cream (P = 0.04). Fusidic acid/hydrocortisone cream was significantly more effective than miconazole/hydrocortisone cream at 1 week in reducing the total sign score (P = 0.001), erythema (P = 0.002), induration (P = 0.001), dryness/scaling (P = 0.02), and cracking/fissuring( P = 0.01). Fusidic acid/hydrocortisone cream was significantly more effective bacteriologically than miconazole/hydrocortisone cream (P = 0.04). Patients considered that treatment-related irritation was significantly more common with fusidic acid/hydrocortisone cream (P = 0.03). Adverse events were recorded in 7 (7.3%) patients given fusidic acid/hydrocortisone and in 8 (7.5%) patients given miconazole/hydrocortisone cream and contributed to treatment withdrawal in 1 (1.0%) patient given fusidic acid/hydrocortisone cream and in 3 (2.8%) patients given miconazole/hydrocortisone cream. Conclusion. Fusidic acid/hydrocortisone cream and miconazole/hydrocortisone cream were equally effective in treating clinically infected eczema. However, fusidic acid/hydrocortisone cream produced a significantly more rapid clinical improvement and was more effective bacteriologically. Both treatments were well tolerated.

Author-supplied keywords

  • Atopic dermatitis
  • Fusidic acid
  • Hydrocortisone
  • Miconazole
  • Staphylococcus aureus
  • Therapy
  • Topical corticosteroid

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Authors

  • T. F. Poyner

  • B. K. Dass

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