Comparative study of SCE induction and cytostatic effects by homo-azasteroidal esters of N,N-bis(2-chloroethyl)aminobenzoic acid in human lymphocytes

  • Mourelatos D
  • Mylonaki E
  • Papageorgiou A
 et al. 
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The effect of homo-azasteroidal esters of benzoic acid mustard isomers and the 4-methyl derivatives, which have steroidal lactams as a biological basis, on cytogenetic damage was studied. Twenty compounds were comparatively studied, on a molar basis, as regards their ability to induce sister-chromatid exchanges (SCEs) and cell division delays. A correlation between potency for SCE induction, effectiveness in cell division delay and previously established antitumor activity of these compounds was observed. © 1995.

Author-supplied keywords

  • Cell kinetics
  • Homo-azasteroidal ester of benzoic acid mustard isomers
  • Sister-chromatid exchange

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  • D MourelatosAristotle University of Thessaloniki

  • E. Mylonaki

  • A. Papageorgiou

  • L. Boutis

  • A. Paradelis

  • A. Anastasiou

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