The effect of homo-azasteroidal esters of benzoic acid mustard isomers and the 4-methyl derivatives, which have steroidal lactams as a biological basis, on cytogenetic damage was studied. Twenty compounds were comparatively studied, on a molar basis, as regards their ability to induce sister-chromatid exchanges (SCEs) and cell division delays. A correlation between potency for SCE induction, effectiveness in cell division delay and previously established antitumor activity of these compounds was observed. © 1995.
CITATION STYLE
Mourelatos, D., Mylonaki, E., Papageorgiou, A., Boutis, L., Paradelis, A., Anastasiou, A., & Catsoulacos, P. (1995). Comparative study of SCE induction and cytostatic effects by homo-azasteroidal esters of N,N-bis(2-chloroethyl)aminobenzoic acid in human lymphocytes. Mutation Research Letters, 346(3), 129–133. https://doi.org/10.1016/0165-7992(95)90044-6
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