Toxicity of two groups of pesticides was studied in adult and newborn rats. The chlorinated group of pesticides, heptachlor, chlordane, and DDT are less toxic in the newborn when compared to the adult, but phenobarbital pretreatment potentiates their toxicity in the newborn. The organophosphorus insecticide, parathion, is more toxic in the newborn when compared to adult, but phenobarbital pretreatment antagonized the toxicity of this cholinesterase inhibitor. Chlorinated pesticides are generally less toxic in the newborn, while the pesticides of the cholinesterase inhibitor group are more toxic. © 1975.
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