Comparison of the mutagenic potency of 2-chloroethanol, 2-bromoethanol, 1,2-epoxybutane, epichlorohydrin and glycidaldehyde in Klebsiella pneumoniae, Drosophila melanogaster and L5178Y mouse lymphoma cells

  • Knaap A
  • Voogd C
  • Kramers P
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Abstract

A series of 2 haloethanols and 3 epoxides was investigated in 3 mutagenicity test systems, namely (1) the fluctuation test in Klebsiella pneumoniae, (2) the sex-linked recessive lethal test in Drosophila melanogaster, and (3) the HGPRT test with L5178Y mouse lymphoma cells. The order of mutagenic potency was, in Klebsiella: glycidaldehyde > 2-bromoethanol = epichlorohydrin > 1,2-epoxybutane > 2-chloroethanol; in Drosophila: glycidaldehyde = epichlorohydrin > 1,2-epoxybutane; in mouse lymphoma cells: epichlorohydrin > 1,2-epoxybutane. The haloethanols were non-mutagenic in Drosophila. 2-Chloroethanol and glycidaldehyde were negative in mouse lymphoma cells. The high mutagenic potency of epichlorohydrin as compared with 1,2-epoxybutane was consistent in all systems, and with published data. © 1982.

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Authors

  • Ada G.A.C. Knaap

  • C. E. Voogd

  • P. G.N. Kramers

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