A concise synthesis of β-lactam-sulfonamide hybrids

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Abstract

Using ring closing metathesis (RCM) as the key operation, a rapid access to β-lactams fused to a sultam moiety of variable ring size was developed from low cost, commercially available starting materials. An efficient RCM of 4-vinyl-azetidin-2-ones to give 1-aza-bicyclo[4.2.0]oct-4-en-8-ones is also reported. © 2004 Elsevier Ltd. All rights reserved.

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Freitag, D., Schwab, P., & Metz, P. (2004). A concise synthesis of β-lactam-sulfonamide hybrids. Tetrahedron Letters, 45(18), 3589–3592. https://doi.org/10.1016/j.tetlet.2004.03.055

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