Convenient and rapid synthesis of α-aminonitriles starting directly from nitro compounds in water

  • Das B
  • Satyalakshmi G
  • Suneel K
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Abstract

A distinct approach for the synthesis of α-aminonitriles has been discovered by three-component reaction of nitroarenes, aldehydes, and TMSCN using indium in dilute aqueous HCl at room temperature. The products were formed in high yields (86-96%) within a short period of time (5-20 min). This one-pot conversion consists of the following steps: (i) reduction of nitro compounds to amines, (ii) formation of imines from amines and aldehydes and (iii) addition of cyanide anion to the imines. © 2009 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Aqueous medium
  • In/HCl
  • Nitro compound
  • TMSCN
  • α-Aminonitriles

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Authors

  • Biswanath Das

  • Gandham Satyalakshmi

  • Kanaparthy Suneel

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