On the coupling between the transport of phosphate and adenine nucleotides in rat liver mitochondria

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Abstract

The effect of specific inhibitors of Pitransport on adenine nucleotide exchange and on oxidative phosphorylation has been investigated. Inhibition of Pitransport causes extensive inhibition of the ADP/ADP exchange and hence of oxidative phosphorylation. The ADP/ADP exchange is unaffected. This effect is probably due to inhibition of electrogenic Pi-transport which partially charge-compensates the ADP3-/ATP4-exchange. © 1971.

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McGivan, J. D., Grebe, K., & Klingenberg, M. (1971). On the coupling between the transport of phosphate and adenine nucleotides in rat liver mitochondria. Biochemical and Biophysical Research Communications, 45(6), 1533–1541. https://doi.org/10.1016/0006-291X(71)90194-X

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