On the coupling between the transport of phosphate and adenine nucleotides in rat liver mitochondria

  • McGivan J
  • Grebe K
  • Klingenberg M
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Abstract

The effect of specific inhibitors of Pitransport on adenine nucleotide exchange and on oxidative phosphorylation has been investigated. Inhibition of Pitransport causes extensive inhibition of the ADP/ADP exchange and hence of oxidative phosphorylation. The ADP/ADP exchange is unaffected. This effect is probably due to inhibition of electrogenic Pi-transport which partially charge-compensates the ADP3-/ATP4-exchange. © 1971.

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