The critical size of active penicillin foci in cat's parietal cortex was determined in two different ways: (a) by gradually enlarging the area of drug application from 0.78 mm2 to 3.14 mm2; (b) by reducing the area of the active penicillin focus, using subpial incisions. Results indicate that a critical area of 0.7 mm2 is necessary. The possibility that in the parietal cortex a single functional column may be the basic generator unit for inter-ictal spikes is discussed. It is concluded that: (a) the size of the critical area is related to the cross-sectional area of a single functional column. This column is not yet determined by parallel anatomical findings; (b) inactivation of a given epileptic focus in the cat's cortex may be achieved by cutting layer III of the focus. © 1979.
Reichenthal, E., & Hocherman, S. (1979). A critical epileptic area in the cat’s cortex and its relation to the cortical columns. Electroencephalography and Clinical Neurophysiology, 47(2), 147–152. https://doi.org/10.1016/0013-4694(79)90216-5