Synthesis of the AB ring segments of ciguatoxin is described. The present synthesis includes a Lewis acid mediated cyclization of allylstannane with aldehyde, cross-metathesis reaction introducing the side chain, and Grieco-Nishizawa dehydration on the A ring. © 2008 Elsevier Ltd. All rights reserved.
Kadota, I., Abe, T., Uni, M., Takamura, H., & Yamamoto, Y. (2008). A cross-metathesis approach to the stereocontrolled synthesis of the AB ring segment of ciguatoxin. Tetrahedron Letters, 49(22), 3643–3647. https://doi.org/10.1016/j.tetlet.2008.03.145