C-type natriuretic peptide increases cyclic GMP in rat cerebral microvessels in primary culture

  • Kobayashi H
  • Ueno S
  • Tsutsui M
 et al. 
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Abstract

Effect of CNP on cGMP level in cultured rat cerebral microvessels was investigated. The cerebral microvessels were prepared from rat cerebral cortex by dispase and collagenase digestion and Percoll gradient centrifugation, and cultured. CNP increased cGMP level in a dose-dependent manner suggesting that CNP has a regulatory role in the cerebral microvessel function. © 1994.

Author-supplied keywords

  • C-type natriuretic peptide
  • Cerebral microvessel
  • Cyclic guanosine monophosphate
  • Natriuretic peptide

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Authors

  • Hideyuki Kobayashi

  • Susumu Ueno

  • Masato Tsutsui

  • Masahiro Okazaki

  • Yasuhito Uezono

  • Nobuyuki Yanagihara

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