Cytogenetic studies of 44 T-cell acute lymphoblastic leukemias

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Abstract

Cytogenetic studies on 44 patients with T-cell acute lymphoblastic leukemia (ALL) were reported. The incidence of leukemia without detectable chromosomal changes was 25%. Hyperdiploidy with more than 50 chromosomes was found in only one patient. Previously described nonrandom abnormalities like 6q-, 9p-, and 12p- were observed, and it was confirmed that they are not specific for a particular type of ALL. The incidence of chromosomal rearrangements on chromosomes 7 and 14 where the T-cell receptor gene loci are located was 36% of those with abnormal karyotypes and 27% of the total. This was clearly different from the frequency of rearrangements of these bands found in T-cell lymphoma. Finally, a rearrangement on bands 11q14-q21 was detected in five cases. © 1990.

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Berger, R., Le Coniat, M., Vecchione, D., Derré, J., & Chen, S. J. (1990). Cytogenetic studies of 44 T-cell acute lymphoblastic leukemias. Cancer Genetics and Cytogenetics, 44(1), 69–75. https://doi.org/10.1016/0165-4608(90)90199-K

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