Cytokine production in lethal and non-lethal murine malaria

  • Lustig Shear H
  • Ng C
  • Zhao Y
  • 4


    Mendeley users who have this article in their library.
  • 15


    Citations of this article.


Levels of IFN-γ, IL-2 and IL-4 were measured in vitro during the course of non-lethal Plasmodium chabaudi adami and lethal P. chabaudi strain 1309 infections in BALB/cByJ mice. Spleen cells from mice infected with the non-lethal Plasmodium had a higher initial response to P. chabaudi antigens than mice infected with P. chabaudi strain 1309, as determined by measuring all three lymphokines. We conclude that both Th1 and Th2 subsets of T helper lymphocytes are activated during P. chabaudi adami infection but that these responses are suppressed in mice infected with the more virulent P. chabaudi strain 1309. © 1990.

Author-supplied keywords

  • IFN-γ
  • IL-2
  • IL-4
  • Intraerythrocytic parasites
  • Macrophage
  • Plasmodium chabaudi
  • Plasmodium chabaudi adami
  • strain 1309

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Hannah Lustig Shear

  • Chui Ng

  • Yi Zhao

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free