A membrane fraction obtained from the post-microsomal supernatant of Novikoff hepatoma and rat tissues has been shown to contain nucleic acid which can stimulate DNA synthesis. Based on the insensitivity to specific RNases and the sensitivity to DNase, the stimulatory nucleic acid is presumed to be DNA. The occurence of this cytoplasmic membrane-associated DNA is related to the proliferative state of the tissue. © 1973.
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