Cytotoxicity, accumulation, and metabolism of deltamethrin, a pyrethroid insecticide, in Drosophila melanogaster cells

3Citations
Citations of this article
6Readers
Mendeley users who have this article in their library.
Get full text

Abstract

The effect and fate of deltamethrin, a potent pyrethroid insecticide, was investigated on embryonic Drosophila melanogaster cells cultured in vitro. The cellular proliferation begins to be significantly affected at 1 μM after 48 hr treatment and the IC50 was 16 μM, a value different from that obtained with intact organisms. [3H]Deltamethrin was quickly accumulated in cells and had a concentration factor of approximately 4000. The pool of insecticide taken up by cells was greater in cells treated by 20-hydroxyecdysone and a part was bound to macromolecules. This binding was strongly reduced after treatment with organic solvents, and electrophoretic studies suggested a noncovalent binding between deltamethrin and proteins. Deltamethrin was partially metabolized in the same way in cells, treated or not by the 20-hydroxyecdysone, by hydrolysis of the ester linkage and conjugation likely preceded by hydroxylation. Hydrolysis products and polar conjugated products were also found in the culture medium. © 1989.

Cite

CITATION STYLE

APA

Baeza-Squiban, A., Best-Belpomme, M., & Marano, F. (1989). Cytotoxicity, accumulation, and metabolism of deltamethrin, a pyrethroid insecticide, in Drosophila melanogaster cells. Pesticide Biochemistry and Physiology, 33(3), 201–212. https://doi.org/10.1016/0048-3575(89)90118-1

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free