Defective proliferative responses in B lymphocytes and thymocytes that lack neurofibromin

  • Kim T
  • Cariappa A
  • Iacomini J
 et al. 
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Abstract

Nf1-/-fetal liver cells were used to reconstitute B and T cells in Rag-1-/-mice. Lymphocyte development was largely unimpaired in the absence of neurofibromin. However antigen-receptor induced proliferation was defective in neurofibromin deficient peripheral B cells and CD4+single positive thymocytes. In contrast to its role as a negative regulator of proliferation in many other cell types, neurofibromin may be a positive regulator of lymphocyte proliferation. Peripheral B cells exhibited circumscribed defects in anti-IgM induced protein tyrosine phosphorylation, which may contribute to the unexpected proliferative defect seen in these cells. © 2002 Elsevier Science Ltd. All rights reserved.

Author-supplied keywords

  • B lymphocytes
  • Cellular activation
  • Signal transduction

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Authors

  • Tae Jin KimSungkyunkwan University School of Medicine

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  • Annaiah Cariappa

  • John Iacomini

  • Mei Tang

  • Shane Shih

  • Andre Bernards

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