Nf1-/- fetal liver cells were used to reconstitute B and T cells in Rag-1-/- mice. Lymphocyte development was largely unimpaired in the absence of neurofibromin. However antigen-receptor induced proliferation was defective in neurofibromin deficient peripheral B cells and CD4+ single positive thymocytes. In contrast to its role as a negative regulator of proliferation in many other cell types, neurofibromin may be a positive regulator of lymphocyte proliferation. Peripheral B cells exhibited circumscribed defects in anti-IgM induced protein tyrosine phosphorylation, which may contribute to the unexpected proliferative defect seen in these cells. © 2002 Elsevier Science Ltd. All rights reserved.
Kim, T. J., Cariappa, A., Iacomini, J., Tang, M., Shih, S., Bernards, A., … Pillai, S. (2002). Defective proliferative responses in B lymphocytes and thymocytes that lack neurofibromin. Molecular Immunology, 38(9), 701–708. https://doi.org/10.1016/S0161-5890(01)00101-8