Delta-9-tetrahydrocannabinol suppresses tumor necrosis factor α maturation and secretion but not its transcription in mouse macrophages

18Citations
Citations of this article
8Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Various in vitro studies have shown that delta-9-tetrahydrocannabinol (THC), the major psychoactive component of marijuana, has a variety of inhibitory effects on immune functions including effects on macrophages. The present studies have examined the mechanism of THC's effects on tumor necrosis factor α (TNF-α), a major macrophage-produced cytokine and an important mediator involved in cytokine networks and in host defense mechanisms. Exposure of macrophages to medium containing THC has resulted in low levels of soluble TNF-α protein and reduced TNF-α bioactivity in the culture supernatant. However, THC did not inhibit the levels of LPS-induced TNF-α mRNA and intracellular TNF-α precursor protein, had only a weak effect on expression of membrane-bound TNF-α, but suppressed TNF-α maturation/secretion by macrophages. The higher the THC concentration in the medium during TNF-α induction, the greater the amount of intracellular TNF-α precursors that accumulated in the activated macrophages and the less mature TNF-α was released from the cells. Data suggest that TNF-α production by macrophages was altered greatly by exposure to THC at the levels of TNF-α precursor maturation and secretion.

Cite

CITATION STYLE

APA

Zheng, Z. M., & Specter, S. C. (1996). Delta-9-tetrahydrocannabinol suppresses tumor necrosis factor α maturation and secretion but not its transcription in mouse macrophages. International Journal of Immunopharmacology, 18(1), 53–68. https://doi.org/10.1016/0192-0561(95)00107-7

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free