Design, synthesis, and biological evaluation of HIV/FIV protease inhibitors incorporating a conformationally constrained macrocycle with a small P3′ residue

15Citations
Citations of this article
2Readers
Mendeley users who have this article in their library.
Get full text

Abstract

A series of norstatine-based HIV/FIV protease inhibitors incorporating a 15-membered macrocycle as a mimic of the tripeptide (Ala-Val-Phe), a motif with a small P3′ residue effective against the FIV protease and the drug-resistant HIV proteases, has been synthesized. It was found that the macrocycle is important to the overall activity of the inhibitors. Certain inhibitors were developed expressing low nanomolar inhibitory activity against the HIV/FIV proteases and they are also effective against some drug-resistant as well as TL3-resistant HIV proteases. © 2001 Elsevier Science Ltd.

Cite

CITATION STYLE

APA

Mak, C. C., Le, V. D., Lin, Y. C., Elder, J. H., & Wong, C. H. (2001). Design, synthesis, and biological evaluation of HIV/FIV protease inhibitors incorporating a conformationally constrained macrocycle with a small P3′ residue. Bioorganic and Medicinal Chemistry Letters, 11(2), 219–222. https://doi.org/10.1016/S0960-894X(00)00641-7

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free