Determination of impurities in nucleoside 3′-phosphoramidites by fast atom bombardment mass spectrometry

  • Toren P
  • Betsch D
  • Weith H
 et al. 
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Abstract

Negative-ion fast atom bombardment mass spectrometry is quite useful for the identification of products and by-products formed during the synthesis of nucleoside 3′-phosphoramidites. The data shown that detritylation and oxidation are side reactions which occur during the synthesis of monomeric units used in the construction of oligodeoxyribonucleotides by the phosphite triester method. © 1986.

Author-supplied keywords

  • mass spectrometry
  • nucleic acid chemistry
  • nucleotides
  • oligonucleotide synthesis
  • organic chemistry
  • phosphoramidites

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Authors

  • Paul C. Toren

  • David F. Betsch

  • H. Lee Weith

  • James M. Coull

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