Development of a liposome-encapsulated radionuclide with preferential tumor accumulation-the choice of radionuclide and chelating ligand

  • Ogihara-Umeda I
  • Sasaki T
  • Nishigori H
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Abstract

Various radionuclide-ligand complexes were encapsulated in liposomes and their accumulations in tumors were studied. Increased tumor accumulation was observed with every complex in the liposome-encapsulated form. However, different accumulation levels were registered for the various radionuclides even though they were all delivered using a similar liposome formulation. Though the liposomes remained intact in the circulation, they were degraded in the tumor, liver and spleen eventually. Thus, this suggests that tumor accumulation of liposome-encapsulated radionuclides is dependent on not only the in vivo behavior of the liposomes themselves, but also the characteristics of nuclide-ligand complexes after their release from liposomes. A correct choice of radionuclides and ligands for encapsulation in liposomes would enable excellent tumor-imaging agents to be achieved. © 1992.

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Authors

  • Izumi Ogihara-Umeda

  • Toru Sasaki

  • Hideo Nishigori

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