Development of a liposome-encapsulated radionuclide with preferential tumor accumulation-the choice of radionuclide and chelating ligand

18Citations
Citations of this article
2Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Various radionuclide-ligand complexes were encapsulated in liposomes and their accumulations in tumors were studied. Increased tumor accumulation was observed with every complex in the liposome-encapsulated form. However, different accumulation levels were registered for the various radionuclides even though they were all delivered using a similar liposome formulation. Though the liposomes remained intact in the circulation, they were degraded in the tumor, liver and spleen eventually. Thus, this suggests that tumor accumulation of liposome-encapsulated radionuclides is dependent on not only the in vivo behavior of the liposomes themselves, but also the characteristics of nuclide-ligand complexes after their release from liposomes. A correct choice of radionuclides and ligands for encapsulation in liposomes would enable excellent tumor-imaging agents to be achieved. © 1992.

Cite

CITATION STYLE

APA

Ogihara-Umeda, I., Sasaki, T., & Nishigori, H. (1992). Development of a liposome-encapsulated radionuclide with preferential tumor accumulation-the choice of radionuclide and chelating ligand. International Journal of Radiation Applications and Instrumentation., 19(7), 753–757. https://doi.org/10.1016/0883-2897(92)90136-M

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free