Development and progression of a Philadelphia-chromosome-negative acute myelocytic leukemia clone in a patient with Philadelphia-chromosome-positive chronic myelocytic leukemia

  • Cullen M
  • Richards S
  • Dickinson H
 et al. 
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Abstract

We report a patient with typical Philadelphia-chromosome-positive chronic myelocytic leukemia who developed Philadelphia-chromosome-negative acute myelocytic leukemia following autologous stem cell transplantation. The implications of this observation for disease monitoring and treatment are discussed. © 2004 Elsevier Inc. All rights reserved.

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Authors

  • Matthew J. Cullen

  • Stephen J. Richards

  • Helen Dickinson

  • Chris Carter

  • David M. Swirsky

  • Roger G. Owen

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