Development and progression of a Philadelphia-chromosome-negative acute myelocytic leukemia clone in a patient with Philadelphia-chromosome-positive chronic myelocytic leukemia

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Abstract

We report a patient with typical Philadelphia-chromosome-positive chronic myelocytic leukemia who developed Philadelphia-chromosome-negative acute myelocytic leukemia following autologous stem cell transplantation. The implications of this observation for disease monitoring and treatment are discussed. © 2004 Elsevier Inc. All rights reserved.

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Cullen, M. J., Richards, S. J., Dickinson, H., Carter, C., Swirsky, D. M., & Owen, R. G. (2004). Development and progression of a Philadelphia-chromosome-negative acute myelocytic leukemia clone in a patient with Philadelphia-chromosome-positive chronic myelocytic leukemia. Cancer Genetics and Cytogenetics, 148(2), 170–173. https://doi.org/10.1016/S0165-4608(03)00277-2

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