Developmental expression of myelin proteins by oligodendrocytes in the CNS of trout

  • Jeserich G
  • Müller A
  • Jacque C
  • 1


    Mendeley users who have this article in their library.
  • 18


    Citations of this article.


Using immunohistochemical techniques, the pattern of cytoplasmic staining and the temporal order of expression of 5 major myelin components of oligodendrocytes were studied in the developing central nervous system of trout. The two myelin glycoproteins, IP1 and IP2, in the cytoplasm of glial cells showed a granular pattern of immunostaining, whereas the 36K protein was homogeneously distributed. Analysis of freshly dissociated cells during early stages of myelinogenesis revealed a constant chronological sequence of expression of myelin proteins by the oligodendrocytes: glycoprotein IP2 was the first protein to appear during glial development together with the galactocerebroside GalC at stage 28 followed by the 36K at stage 30 and finally IP1 at stage 32. The deposition of myelin proteins into the nascent myelin sheath occurred in the same chronological order as their expression by oligodendrocytes. Moreover myelin basic protein, which was not detectable in glial cells, on tissue sections was found to appear in parallel with IP2. © 1990.

Author-supplied keywords

  • Development
  • Myelin protein
  • Oligodendrocyte
  • Trout CNS

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • G. Jeserich

  • A. Müller

  • C. Jacque

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free