Dietary metformin effects on in vitro and in vivo metabolism in the chicken

0Citations
Citations of this article
5Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Chickens were fed diets containing 0, 0.25, 0.5, and 1 and 0, 2.5, 5, and 10 g metformin (MET)/kg diet in 2 separate experiments to determine whether MET (1,1 dimethylbiguanidine hydrochloride) regulated plasma glucose and, possibly, feed intake in broiler chickens. Feed intakes in the first experiment were equal, but, in the second experiment, MET at 5 and 10 g/kg reduced feed intake. The first series of diets had no effect on plasma glucose and lactate. The second series of dietary treatments did not affect plasma glucose but did increase plasma lactate, uric acid, and triglycerides linearly. In the second experiment, there were significant decreases in lipogenesis that accompanied increasing doses of MET. The increase in plasma lactic acid suggests that MET stimulates pyruvate kinase in the chicken, as it does in mammals. The lack of effect on plasma glucose also suggests that regulation occurs downstream of pyruvate in the chicken. These findings may explain MET's ability to reduce hepatic triglyceride synthesis and suppress appetite.

Cite

CITATION STYLE

APA

Rosebrough, R. W., & Ashwell, C. M. (2005). Dietary metformin effects on in vitro and in vivo metabolism in the chicken. Nutrition Research, 25(5), 491–497. https://doi.org/10.1016/j.nutres.2005.03.001

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free