Different role of endothelin ETAand ETBreceptors and endothelial modulators in diabetes-induced hyperreactivity of the rabbit carotid artery to endothelin-1

15Citations
Citations of this article
5Readers
Mendeley users who have this article in their library.
Get full text

Abstract

The influence of diabetes on regulatory mechanisms and specific receptors implicated in the contractile response of isolated rabbit carotid arteries to endothelin-1 was examined. Endothelin-1 induced a concentration-dependent contraction that was greater in arteries from diabetic rabbits than in arteries from control rabbits. Endothelium removal or NG-nitro-L-arginine enhanced contractions in response to endothelin-1 only in control arteries, without modifying the endothelin-1 response in diabetic arteries. Indomethacin, furegrelate (thromboxane A2inhibitor), or cyclo-(D-Asp-Pro-D-Val- Leu-D-Trp) (BQ-123; endothelin ETAreceptor antagonist) inhibited the contractions in response to endothelin-1, the inhibition being greater in diabetic arteries than in control arteries. 2,6-Dimethylpiperidinecarbonyl- γ-methyl-Leu-Nin-(methoxycarbonyl)-D-Trp-D-Nle (BQ-788; endothelin ETBreceptor antagonist) enhanced the contraction elicited by endothelin-1 in control arteries and displaced to the right the contractile curve for endothelin-1 in diabetic arteries. In summary, diabetes induces hyperreactivity of the rabbit carotid artery to endothelin-1 by a mechanism that at least includes: (1) enhanced activity of muscular endothelin ETAreceptors; (2) impairment of endothelin ETBreceptor-mediated nitric oxide (NO) release; and (3) enhancement of the production of thromboxane A2. © 2004 Elsevier B.V. All rights reserved.

Cite

CITATION STYLE

APA

Lloréns, S., Miranda, F. J., Alabadí, J. A., Marrachelli, V. G., & Alborch, E. (2004). Different role of endothelin ETAand ETBreceptors and endothelial modulators in diabetes-induced hyperreactivity of the rabbit carotid artery to endothelin-1. European Journal of Pharmacology, 486(1), 43–51. https://doi.org/10.1016/j.ejphar.2003.12.003

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free