Different sensitivities of the responses of human neutrophils stimulated with immune complex and C5a anaphylatoxin to pertussis toxin

  • Shirato M
  • Takahashi K
  • Nagasawa S
 et al. 
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Abstract

When stimulated with immune complex or C5a anaphylatoxin, human neutrophils undergo an increase in the concentration of intracellular Ca2+([Ca2+]i) that precedes the onset of superoxide (O-2) production. The extracellular Ca2+is required for the O-2production of neutrophils stimulated by C5a, but is only partially required for those by immune complex. The addition of pertussis toxin to neutrophils does not inhibit the rise in [Ca2+]iand O-2production induced by immune complex but does inhibit those induced by C5a. These results suggest that a different sequence of reaction is involved by different stimulants, the anaphylatoxin and immune complex. © 1988.

Author-supplied keywords

  • C5a
  • Immune complex
  • Neutrophil
  • Pertussis toxin

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Authors

  • Manabu Shirato

  • Kazuhiko Takahashi

  • Shigeharu Nagasawa

  • Jiro Koyama

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