Differential binding of RNA polymerase to the wild type Mu mom promoter and its C independent mutant: a theoretical analysis

  • Murlidharan Nair T
  • Kulkarni B
  • Nagaraja V
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Using the theoretical model for DNA bending we have analyzed the Mu mom promoter wild type and its mutant tin7 which showed differential binding to the RNA polymerase. We have demonstrated here the structural change as a result of the point mutation which may be responsible for the altered binding of RNA polymerase. Analysis using both sets of parameters essentially gives the same result. © 1995.

Author-supplied keywords

  • DNA curvature
  • Promoter structure
  • RNA polymerase

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