Discriminative stimulus properties of cocaine related to an anxiogenic action

  • Shearman G
  • Lal H
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Abstract

1. 1. Male hooded rats were trained to discriminate the anxiogenic action of phentylenetetrazol by responding for food reinforcement with a lever located on one side of a food cup 15 min following a 20 mg/kg pentylenetetrazol injection and responding with the lever located on the alternate side of the food cup 15 min following a 1 ml/kg saline injection. 2. 2. Cocaine (20 mg/kg) but not diazepam (5 mg/kg) nor haloperidol (0.16 or 0.64 mg/kg) significantly generalized to the pentylenetrazol discriminative stimulus. 3. 3. Diazepam (5 mg/kg) but not haloperidol (0.16 or 0.64 mg/kg) significantly antagonized the discriminative stimuli produced by pentylenetetrazol and cocaine. 4. 4. These data suggest that cocaine produces discriminative stimulus that is related to its anxiogenic action. © 1981.

Author-supplied keywords

  • anxiety
  • cocaine
  • diazepam
  • drug discrimination
  • haloperidol
  • pentylenetetrazol

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Authors

  • Gary T. Shearman

  • Harbans Lal

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