DOI is a mixed agonist-antagonist at postjunctional 5-HT2receptors in the pithed rat

  • Dabiré H
  • Chaouche-Teyara K
  • Cherqui C
 et al. 
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Abstract

The maximal pressor effect induced by DOI in the pithed rat was smaller than that induced by 5-HT, suggesting partial agonistic properties of DOI. DOI shifted the dose-pressor response curve of 5-HT to the right. It is concluded that, in addition to its 5-HT2agonistic properties, DOI also possesses 5-HT2antagonistic properties in the pithed rat. © 1989.

Author-supplied keywords

  • (1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane
  • (Partial agonism)
  • 5-HT2receptors
  • DOI

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Authors

  • Hubert Dabiré

  • Kamel Chaouche-Teyara

  • Claudie Cherqui

  • Berthe Fournier

  • Henri Schmitt

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