The maximal pressor effect induced by DOI in the pithed rat was smaller than that induced by 5-HT, suggesting partial agonistic properties of DOI. DOI shifted the dose-pressor response curve of 5-HT to the right. It is concluded that, in addition to its 5-HT2agonistic properties, DOI also possesses 5-HT2antagonistic properties in the pithed rat. © 1989.
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