The maximal pressor effect induced by DOI in the pithed rat was smaller than that induced by 5-HT, suggesting partial agonistic properties of DOI. DOI shifted the dose-pressor response curve of 5-HT to the right. It is concluded that, in addition to its 5-HT2agonistic properties, DOI also possesses 5-HT2antagonistic properties in the pithed rat. © 1989.
Dabiré, H., Chaouche-Teyara, K., Cherqui, C., Fournier, B., & Schmitt, H. (1989). DOI is a mixed agonist-antagonist at postjunctional 5-HT2receptors in the pithed rat. European Journal of Pharmacology, 170(1–2), 109–111. https://doi.org/10.1016/0014-2999(89)90143-X