Drug-induced modulation of IL-2 production in experimental murine trypanosomiasis

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In this study we evaluated the effects of N-acetyl-cysteine and indomethacin in restoring IL-2 producing ability in vitro of splenocytes from mice infected with Trypanosoma equiperdum. Spleen cells from these mice were found to produce significantly lower levels of interleukin-2 (IL-2) in response to mitogen stimulation than spleen cells from uninfected control mice. This was accompanied by considerable suppression of IL-2-receptor expression, which was not attributable to the elimination of a particular T-cell subset. Impairment of IL-2 production was not due to a primary defect in L3T4+ T-cells, but rather to the presence of both adherent and non-adherent suppressor cells that apparently acted via prostaglandin-independent and dependent mechanisms. In fact, the IL-2-producing ability of lymphocytes from infected mice could be efficiently restored by in vitro exposure to N-acetyl-cysteine or indomethacin. © 1992.




Calabresi, A., Perito, S., Romani, L., & Bistoni, F. (1992). Drug-induced modulation of IL-2 production in experimental murine trypanosomiasis. International Journal of Immunopharmacology, 14(7), 1165–1173. https://doi.org/10.1016/0192-0561(92)90051-L

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