An easy access to (S)-pyrrolidinones and -pyrrolidines from chiral benzylic malonates

  • Arzel P
  • Freida V
  • Weber P
 et al. 
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Abstract

From chiral benzylic malonic acid esters (R)-(+)-4, available with high enantiomeric excesses by enzymatic hydrolysis (PLE acetonic powder), enantiomerically enriched pyrrolidinones 1 and pyrrolidines 2 were prepared. This rapid and competitive method was developed via enol ether formation, and subsequent one-pot cyclisation, in good overall yield.

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Authors

  • Philippe Arzel

  • Vincent Freida

  • Philippe Weber

  • Antoine Fadel

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