Echinostoma paraensei and Schistosoma mansoni: Adherence of unaltered or modified latex beads to hemocytes of the host snail Biomphalaria glabrata

  • Uchikawa R
  • Loker E
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Abstract

Hemocytes derived from a strain (13-16-R1) of Biomphalaria glabrata resistant to Schistosoma mansoni were significantly more likely to bind untreated latex beads than hemocytes from the schistosome-susceptible M line strain. Beads preincubated in 13-16-R1 plasma were more readily bound by both 13-16-R1 and M line hemocytes than beads preincubated in M line plasma. Beads preincubated in plasma derived from snails of either strain infected with the trematode Echinostoma paraensei were more readily bound by hemocytes than beads preincubated in plasma from control snails of the corresponding strain. Plasma from snails exposed to S. mansoni did not have a similar effect. Throughout these experiments, beads receiving a particular treatment were consistently bound at higher rates by 13-16-R1 than M line hemocytes. SDS-PAGE of plasma components eluted from beads revealed differences between treatments, particularly in diffuse bands falling into two groups, of 75-130 and 150-220 kDa. The results indicate that both hemocytes and plasma components from the two host strains differ and identify plasma molecules deserving of additional study as possible modulators of hemocyte effector functions. Also, S. mansoni and E. paraensei provoked different responses in the same host snail. © 1992.

Author-supplied keywords

  • Biomphalaria glabrata
  • Cell adherence
  • Comparative immunobiology
  • Echinostoma paraensei
  • Hemocytes
  • Mollusca
  • Non-self-recognition
  • Schistosoma mansoni
  • Trematoda

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Authors

  • Ryuichi Uchikawa

  • Eric S. Loker

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