Objective: To determine in vitro free ion concentration in three standard artificial enteral feeding formulas following the addition of ion exchange resins. Method: Three standard types of AEF were chosen: Osmolite HN®, Nutrison Standard®and Isosource Standard®. The ion exchange resins used were: Sodium Polystyrene Sulfonate and Calcium Polystyrene Sulfonate. 100 ml of AEF were mixed in a beaker with 1.5 g or 3 g of ion exchange resins for 48 hours at 37°C. Subsequently, the samples were precipitated and the supernatant obtained was used for determining the concentrations of calcium, magnesium, sodium and potassium ions. Results: The addition of Sodium Polystyrene Sulfonate to different types of enteral feeding formulas reduced the concentrations of potassium, calcium and magnesium ions by 70%. 78.2%, and 77.6% in the case of Osmolite HN®; by 72.3%, 69.2% and 63.5% in the case of Nutrison Standard®, and by 78.3%, 80.5% and 74.5% in the case of Isosource Standard®. In contrast, the addition of Calcium Polystyrene Sulfonate reduced the concentration of potassium and magnesium by 50.5% and 55.5% in the case of Osmolite HN®; by 49.8% and 43% in the case of Nutrison Standard®and by 42.6% and 37.7% in the case of Isosource Standard®. Conclusions: The addition of ion exchange resins to different types of enteral feeding formulas, allows the in vitro free ion content of these to be reduced. © 2008 Sociedad Española de Farmacia Hospitalaria.
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