The effect of bone marrow mononuclear cells on vascularization and bone regeneration in steroid-induced osteonecrosis of the femoral head

  • Sun Y
  • Feng Y
  • Zhang C
  • 4

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Abstract

OBJECTIVE: We examined whether implantation of autologous bone marrow mononuclear cells (BM-MNC) can augment neovascularization and bone regeneration in steroid-induced osteonecrosis of the femoral head. METHODS: Sixty-five 28-week-old male New Zealand white rabbits were divided into group I (left untreated, N=20), group II (core decompression, N=20) and group III (core decompression+autologous bone marrow cells implantation, N=25) after receiving an established inductive protocol for inducing steroid-associated ON. Four weeks later, these rabbits were euthanized, bilateral femora were dissected for micro-CT-based microangiography to assess vascularization, and then the osteonecrotic changes and repair processes were examined histopathologically. RESULTS: Quantitative analysis showed that new vessel formation in group III was significantly greater compared with other groups at 4 weeks after treatment. Penetrating capillary vessels number vessels number in group III (44.5+/-5.11) was significantly larger than that of group II (11.4+/-2.46) and group I (3.10+/-0.33) (p

Author-supplied keywords

  • Angiography
  • Animals
  • Bone Marrow Transplantation/*methods
  • Bone Regeneration/physiology
  • Capillaries/radiography
  • Decompression, Surgical
  • Disease Models, Animal
  • Femur Head Necrosis/chemically induced/pathology/*
  • Femur Head/blood supply/*pathology
  • Leukocytes, Mononuclear/*transplantation
  • Male
  • Methylprednisolone/toxicity
  • Rabbits

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Authors

  • Y Sun

  • Y Feng

  • C Zhang

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