Effect of fresh guinea-pig serum on the toxicity of Bordetella pertussis and Bordetella parapertussis

  • Spasojevic-Rabrenovic V
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Abstract

The effect of fresh guinea-pig serum on the toxicity of Bordetella pertussis and B. parapertussis has been investigated. Cultures were grown on Bordet-Gengou medium, mixed with fresh guinea-pig serum and injected into mice by the intraperitoneal route. Much lower LDse values were found when the animals were injected with mixtures of B. pertussis and guinea-pig serum. The cultures of 12 B. pertussis strains showed LDses between 1·10 and 3·25 billion bacteria after the addition of fresh guinea-pig serum. The LDse values of the control cultures ranged between 2·68 and 8·06 billion bacteria. Compared with the controls the LDses of the cultures mixed with fresh guinea-pig serum were significantly lower (P

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Authors

  • Vera Spasojevic-Rabrenovic

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