Studies on the effects of gluten-free diet (GFD) on bone mineral metabolism have given no univocal results in children and adults with celiac disease. Bone mineral metabolism was assessed in 23 celiac children, aged 1 to 12 years (mean 4.6) at moment of diagnosis (T0) and after 12 months of GFD (T12) without any vitamin D supplementation. At T0, calcium, phosphates and alkaline phosphatase values were within the normal range in all but few subjects, but their respective average values significantly rose at T12. The percentages of low values of bone mineral density and of osteocalcin at T0were significantly higher than those at T12and their respective average values significantly increased between To and T12. Circulating parathyroid hormone values were within the normal range in all patients at T10and T12, with no significant difference in average values between To and T12. One year of GFD is sufficient to obtain a complete restoration of bone mineral density even without vitamin D supplementation. The normal levels of parathyroid hormone and the reduced osteocalcin at diagnosis suggest that in young celiac children there is no important rise in bone remodeling.
Rea, F., Polito, C., Iovene, A., Pluvio, R., Rea, L., Piscitelli, A., & Rossiello, R. (1998). Effect of gluten-free diet on bone mineral metabolism of celiac children. Nutrition Research, 18(10), 1661–1666. https://doi.org/10.1016/S0271-5317(98)00150-X