Effect of human immunodeficiency virus type 1 protease inhibitor therapy and subtype on development of resistance in subtypes B and G

  • Palma A
  • Abecasis A
  • Vercauteren J
 et al. 
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Abstract

Europe is currently observing a significant rise in non-B subtypes. Consequently, the effect of genetic variability on therapy response or genotypic resistance interpretation algorithms is an emerging concern. The purpose of this study is to investigate the amino acid substitutions selected under drug pressure in the protease of human immunodeficiency virus type 1 (HIV-1) subtypes B and G, and determine if there are any significant differences. We investigated therapy-related and subtype-related substitutions in the protease, considering subtype, overall protease inhibitor treatment and individual drug exposure. Many mutations were significantly related to protease inhibitor (PI) therapy, with mutations exclusive to subtype B or subtype G. Some mutations are at positions related to resistance in both subtypes, but the amino acid substitution is different. Other mutations were significantly associated with subtype and PI selective pressure (p

Author-supplied keywords

  • *HIV Infections/drug therapy/virology
  • *HIV-1/drug effects/genetics
  • Amino Acid Substitution/drug effects
  • Drug Resistance, Viral/*genetics
  • Genetic Variation
  • HIV Protease Inhibitors/*therapeutic use
  • HIV Protease/*genetics
  • Humans
  • Indinavir/therapeutic use
  • Lopinavir
  • Phylogeny
  • Pyrimidinones/therapeutic use
  • Selection, Genetic
  • Sequence Analysis, Protein

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Authors

  • A C Palma

  • A B Abecasis

  • J Vercauteren

  • A P Carvalho

  • J Cabanas

  • A M Vandamme

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