Effect of intracisternal administration of prostaglandin E1on waking and sleep in the rat

  • Mašek K
  • Kadlecová O
  • Pöschlová N
  • 1


    Mendeley users who have this article in their library.
  • 12


    Citations of this article.


Intracisternal injection of 50 μg/kg prostaglanclin E1(PGE1) to rats was followed by a marked decrease of the paradoxical phase of sleep in the second and third hour after prostaglandin injection. The administration of 6-hydroxydopamine, which lowered the total level of noradrenaline to 40% and dopamine to 50% of control value, decreased the total time the animals spent in paradoxical sleep by 50%. The injection of PGE1to 6-hydroxydopamine-treated rats further decreased the time that animals spent in paradoxical sleep. However, the total time of paradoxical sleep in intact and 6-hydroxydopamine-treated animals injected with PGE was about equal i.e. 10-15% of control values. © 1976.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • K. Mašek

  • O. Kadlecová

  • N. Pöschlová

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free