Intracisternal injection of 50 μg/kg prostaglanclin E1(PGE1) to rats was followed by a marked decrease of the paradoxical phase of sleep in the second and third hour after prostaglandin injection. The administration of 6-hydroxydopamine, which lowered the total level of noradrenaline to 40% and dopamine to 50% of control value, decreased the total time the animals spent in paradoxical sleep by 50%. The injection of PGE1to 6-hydroxydopamine-treated rats further decreased the time that animals spent in paradoxical sleep. However, the total time of paradoxical sleep in intact and 6-hydroxydopamine-treated animals injected with PGE was about equal i.e. 10-15% of control values. © 1976.
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