The effect of metoclopramide on the ganzfeld electroretinogram

  • Jaffe M
  • Levinson P
  • Zimmlichman R
 et al. 
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Abstract

Antecedent light flashes enhance the amplitude of the electroretinogram (ERG) oscillatory potentials, but do not modify other ERG responses nor dark-adaptation sensory thresholds. Metoclopramide infusion (i.v.) has a generally attenuating effect on the ERG, which is more evident under conditions of dark- than light-adaptation. Metoclopramide decreases the peak amplitude of the rod b-wave and the dark-adapted cone b-wave in a similar manner, it also significantly increases the implicit time of the rod b-wave-wave, but not of the dark-adapted cone b-wave. In addition metoclopramide reverses the enhancement of the oscillatory potentials by the antecedent light flashes. © 1987.

Author-supplied keywords

  • D2 antagonist
  • Dopamine
  • Ganzfeld electroretinogram
  • Human
  • Metoclopramide

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Authors

  • M. J. Jaffe

  • P. D. Levinson

  • R. Zimmlichman

  • J. C. Coen

  • C. N. Karson

  • F. M. de Monasterio

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