Effect of oral rotavirus/iscom vaccines on immune responses in gnotobiotic lambs

  • Van Pinxteren L
  • Bruce M
  • Campbell I
 et al. 
  • 4

    Readers

    Mendeley users who have this article in their library.
  • 18

    Citations

    Citations of this article.

Abstract

A comparison of the effect on the immune responses in gnotobiotic lambs was made between an iscom vaccine prepared from recombinant rotavirus VP6 protein, an inactivated rotavirus/iscom-matrix vaccine and a vaccine comprising inactivated rotavirus alone. All three vaccines induced immunological priming and some degree of protection was observed after a single oral dose. However, different immune responses were induced in response to a virulent infection. The group vaccinated with the rotavirus/iscom-matrix vaccine showed a Th2-like response characterised by rotavirus-specific antibodies and a down-regulation of IFNγ in jejunal Peyer's patches. Both Th1-like and Th2-like immune responses were induced in the group receiving the VP6 vaccine as seen by significantly increased expressions of IFNγ and IL-6 in the jejunal Peyer's patch together with an increased percentage of CD8+T cells in the intestine and rotavirus-specific antibodies at mucosal surfaces. Iscom vaccines given orally have the ability to induce both Th1-like and Th2-like immune responses in a ruminant model. Copyright (C) 1999 Elsevier Science B.V.

Author-supplied keywords

  • Iscoms
  • Lambs
  • Rotavirus
  • Th1/Th2-type cytokines

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Laurens A.H. Van Pinxteren

  • Maureen G. Bruce

  • Iris Campbell

  • Ann Wood

  • Christopher J. Clarke

  • Anna Bellman

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free