1. 1. A single injection of oxaloacetate into Tilapia mossambica caused a rapid depletion of liver glycogen. A series of six injections given over a 72-hr period kept liver glycogen levels low and caused a marked increase in a liver size. 2. 2. After removal of oxaloacetate, liver weight continued to increase for about 36 hr and then decreased. Liver glycogen rose steadily for 108 hr, and then fell sharply. A net synthesis of liver glycogen was observed. 3. 3. Two injections of ACTH, or six injections of cortisol, after oxaloacetate, served to stimulate liver glycogen synthesis. © 1970.
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